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[alexis]

TIF images lose sharpness

Saving a compressed TIF from a JPG file is pointless. So, unless you're working with raw Photoshop files, saving as TIF will not be an advantage. Let's assume you are indeed working with Photoshop files.

Saving as a TIF gives you three options in image compression:
1) NONE
2) LZW
3) ZIP

Make sure the image mode is set to CMYK, and NOT "Indexed Color" ... while you can save an indexed color image to TIF, it's not recommended.

To retain ALL of the fidelity of the image, check the "NONE" setting. This might result in a very large file, but you'll retain all of the sharpness.

You should also flatten the file before saving, and use "Save As..." so the original file stays untouched.

If "Layer Compression" is not grayed out, that means you still have layers in the file, and you should use RLE compression.